BDBM719396 3-chloro-4-((1S,2S)-2-(6-chloro-3-oxo-3,4-dihydropyrazin-2-yl)cyclopropyl)-3''-::US20250051309, Example 4.101

SMILES Cc2cnc(c1cccc(S(C)(=O)=O)c1F)c(F)c2n5c(C)cc([C@H]3C[C@@H]3c4nc(Cl)c[nH]c4=O)c(Cl)c5=O

InChI Key InChIKey=QVELPJBQWXPQJO-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 719396   

TargetMitogen-activated protein kinase 14/1(Human)
Gilead Sciences

US Patent
LigandPNGBDBM719396(3-chloro-4-((1S,2S)-2-(6-chloro-3-oxo-3,4-dihydrop...)
Affinity DataIC50: 0.300nMAssay Description:In a 20 μL reaction, the compounds of various concentrations (20 nL) were pre-incubated with 0.6 nM MK2 (Abcam #ab79910) and 0.06 nM active p38α (Abc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
US Patent

LigandPNGBDBM719396(3-chloro-4-((1S,2S)-2-(6-chloro-3-oxo-3,4-dihydrop...)
Affinity DataIC50: 6.30nMAssay Description:In a 10 μL reaction, the compounds of various concentrations (10 nL) were pre-incubated with 3 nM active p38 at (Abcam #ab271606 or in-house prepared...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
US Patent