BDBM719541 3-(3-chloro-4-((1S,2S)-2-(5-chloropyridin-3-yl)cyclopropyl)-3''-fluoro-5'',6-::US20250051309, Example 5.45

SMILES CNC(=O)c5cccc(c4ncc(C)c(n3c(C)cc([C@H]1C[C@@H]1c2cncc(Cl)c2)c(Cl)c3=O)c4F)c5F

InChI Key InChIKey=IRHZIZQNZWWCOP-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 719541   

TargetMitogen-activated protein kinase 14/1(Human)
Gilead Sciences

US Patent
LigandPNGBDBM719541(3-(3-chloro-4-((1S,2S)-2-(5-chloropyridin-3-yl)cyc...)
Affinity DataIC50: 0.300nMAssay Description:In a 20 μL reaction, the compounds of various concentrations (20 nL) were pre-incubated with 0.6 nM MK2 (Abcam #ab79910) and 0.06 nM active p38α (Abc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
US Patent

LigandPNGBDBM719541(3-(3-chloro-4-((1S,2S)-2-(5-chloropyridin-3-yl)cyc...)
Affinity DataIC50: 11.8nMAssay Description:In a 10 μL reaction, the compounds of various concentrations (10 nL) were pre-incubated with 3 nM active p38 at (Abcam #ab271606 or in-house prepared...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
US Patent