BDBM719594 3-(3-chloro-3''-fluoro-4-((1S,2S)-2-(5-fluoropyridin-3-yl)cyclopropyl)-5'',6-::US20250051309, Example 6.35

SMILES Cc3cnc(c2cccc(C(=O)NC1CC1)c2F)c(F)c3n6c(C)cc([C@H]4C[C@@H]4c5cncc(F)c5)c(Cl)c6=O

InChI Key InChIKey=QDOZHMYJWLOMAS-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 719594   

TargetMitogen-activated protein kinase 14/1(Human)
Gilead Sciences

US Patent
LigandPNGBDBM719594(3-(3-chloro-3'-fluoro-4-((1S,2S)-2-(5-fluoropyridi...)
Affinity DataIC50: 0.400nMAssay Description:In a 20 μL reaction, the compounds of various concentrations (20 nL) were pre-incubated with 0.6 nM MK2 (Abcam #ab79910) and 0.06 nM active p38α (Abc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
US Patent

LigandPNGBDBM719594(3-(3-chloro-3'-fluoro-4-((1S,2S)-2-(5-fluoropyridi...)
Affinity DataIC50: 11nMAssay Description:In a 10 μL reaction, the compounds of various concentrations (10 nL) were pre-incubated with 3 nM active p38 at (Abcam #ab271606 or in-house prepared...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
US Patent