BDBM719625 3-chloro-3'',3$#8243;-difluoro-4-((1S,2S)-2-(5-fluoropyridin-3-yl)cyclopropyl)-5'',6-::US20250051309, Example 6.66

SMILES Cc1ncn(-c2nccc(-c3ncc(C)c(-n4c(C)cc([C@H]5C[C@@H]5c5cncc(F)c5)c(Cl)c4=O)c3F)c2F)n1

InChI Key InChIKey=XZHVESSSRWBYAX-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 719625   

TargetMitogen-activated protein kinase 14/1(Human)
Gilead Sciences

US Patent
LigandPNGBDBM719625(3-chloro-3',3$#8243;-difluoro-4-((1S,2S)-2-(5-fluo...)
Affinity DataIC50: 0.600nMAssay Description:In a 20 μL reaction, the compounds of various concentrations (20 nL) were pre-incubated with 0.6 nM MK2 (Abcam #ab79910) and 0.06 nM active p38α (Abc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
US Patent

LigandPNGBDBM719625(3-chloro-3',3$#8243;-difluoro-4-((1S,2S)-2-(5-fluo...)
Affinity DataIC50: 33.4nMAssay Description:In a 10 μL reaction, the compounds of various concentrations (10 nL) were pre-incubated with 3 nM active p38 at (Abcam #ab271606 or in-house prepared...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
US Patent