BDBM719724 N-((5-(2-((5-methyloxazolo[4,5- b]pyridin-2- yl)thio)acetyl)thiophen-2- yl)methyl)pivalamide::US20250051319, Compound 23::US12421222, Compound 23

SMILES Cc1ccc2oc(SCC(=O)c3ccc(CNC(=O)C(C)(C)C)s3)nc2n1

InChI Key InChIKey=BLBCCVCLTZDRRV-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 719724   

TargetHistone deacetylase 6(Human)
Augustine Therapeutics

US Patent
LigandPNGBDBM719724(N-((5-(2-((5-methyloxazolo[4,5- b]pyridin-2- yl)th...)
Affinity DataIC50: 100nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/8/2026
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
Augustine Therapeutics

US Patent
LigandPNGBDBM719724(N-((5-(2-((5-methyloxazolo[4,5- b]pyridin-2- yl)th...)
Affinity DataIC50: 100nMAssay Description:Inhibition of HDAC enzymes was performed in 384-well plate format using human full-length recombinant HDAC1 and HDAC6, isolated from a baculovirus ex...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
Augustine Therapeutics

US Patent
LigandPNGBDBM719724(N-((5-(2-((5-methyloxazolo[4,5- b]pyridin-2- yl)th...)
Affinity DataIC50: 300nMAssay Description:NanoBRET target engagement was performed against the catalytic domain 2 (CD2) of HDAC6, with minor modifications of kit manufacturer protocol (Promeg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
Augustine Therapeutics

US Patent
LigandPNGBDBM719724(N-((5-(2-((5-methyloxazolo[4,5- b]pyridin-2- yl)th...)
Affinity DataIC50: 2.17E+3nMAssay Description:Inhibition of HDAC enzymes was performed in 384-well plate format using human full-length recombinant HDAC1 and HDAC6, isolated from a baculovirus ex...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Augustine Therapeutics

US Patent
LigandPNGBDBM719724(N-((5-(2-((5-methyloxazolo[4,5- b]pyridin-2- yl)th...)
Affinity DataIC50: 5.50E+3nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/8/2026
Entry Details
US Patent