BDBM719863 2-methoxy-N-((5-(2-((6-methoxy- 2-methylpyrido[2,3-d]pyrimidin-4- yl)thio)acetyl)thiophen-2- yl)methyl)acetamide::US20250051319, Compound 163::US12421222, Compound 163

SMILES COCC(=O)NCc1ccc(C(=O)CSc2nc(C)nc3ncc(OC)cc23)s1

InChI Key InChIKey=ZQFLRAYREGDBHH-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 719863   

TargetHistone deacetylase 6(Human)
Augustine Therapeutics

US Patent
LigandPNGBDBM719863(2-methoxy-N-((5-(2-((6-methoxy- 2-methylpyrido[2,3...)
Affinity DataIC50: 100nMAssay Description:Dose response testing of HDAC6 and HDAC 1 were run at Reaction Biology Corporation (RBC). Inhibition of HDAC enzymes was performed using N-terminal G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
Augustine Therapeutics

US Patent
LigandPNGBDBM719863(2-methoxy-N-((5-(2-((6-methoxy- 2-methylpyrido[2,3...)
Affinity DataIC50: 100nMAssay Description:Table 8: Dose response testing of HDAC6 and HDAC 1 were run at Reaction Biology Corporation (RBC). Inhibition of HDAC enzymes was performed using N-t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/8/2026
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
Augustine Therapeutics

US Patent
LigandPNGBDBM719863(2-methoxy-N-((5-(2-((6-methoxy- 2-methylpyrido[2,3...)
Affinity DataIC50: 100nMAssay Description:NanoBRET target engagement was performed against the catalytic domain 2 (CD2) of HDAC6, with minor modifications of kit manufacturer protocol (Promeg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent