BDBM720220 preparation of 6-(4-((8-methyl-6-oxo-7-(trifluoromethyl)-5,6-dihydro-1,5-naphthyridin-3-yl)methyl)piperazin-1-yl)nicotinonitrile ::US20250051324, Example 20

SMILES CC1=C(C(F)(F)F)C(=O)Cc2cc(CN3CCN(c4ccc(C#N)cn4)CC3)cnc21

InChI Key InChIKey=VAOSPAAWVHKOHD-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 720220   

TargetPoly [ADP-ribose] polymerase 1(Human)
Keythera (Suzhou) Bio-Pharmaceuticals

US Patent
LigandPNGBDBM720220(preparation of 6-(4-((8-methyl-6-oxo-7-(trifluorom...)
Affinity DataIC50: 1.26nMAssay Description:The PARP1 assay kit was purchased from BPS Bioscience, USA, specifically the 384-well chemiluminescent assay kit (Catalog No.: #80551).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent