BDBM720659 (R)-4-(2-(1H-indol-4-yl)-7-(methylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-methylmorpholine ::US20250051362, Compound 18::US12435095, Compound 18

SMILES C[C@@H]1COCCN1c1nc(-c2cccc3[nH]ccc23)nc2c1ccn2S(C)(=O)=O

InChI Key InChIKey=UTWDLQNUMKSECR-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 720659   

LigandPNGBDBM720659((R)-4-(2-(1H-indol-4-yl)-7-(methylsulfonyl)-7H-pyr...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of ATR/ATRIP (unknown origin) using 5-FAM-AK-17 as substrate preincubated with compound for 10 mins followed by ATP addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Shanghai Annova Biotechnology

US Patent
LigandPNGBDBM720659((R)-4-(2-(1H-indol-4-yl)-7-(methylsulfonyl)-7H-pyr...)
Affinity DataIC50: 2.30nMAssay Description:The inhibitory activity of the compounds on ATR kinase in vitro was determined by Mobility Shift Assay at an ATP concentration of Km using Caliper EZ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
Shanghai Annova Biotechnology

US Patent
LigandPNGBDBM720659((R)-4-(2-(1H-indol-4-yl)-7-(methylsulfonyl)-7H-pyr...)
Affinity DataIC50: 2.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details US Patent