BDBM72120 2-(4-keto-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)-1-[2-(trifluoromethyl)phenyl]guanidine::2-(4-oxidanylidene-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)-1-[2-(trifluoromethyl)phenyl]guanidine::2-(4-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)-1-[2-(trifluoromethyl)phenyl]guanidine::MLS000582855::N-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-N'-[2-(trifluoromethyl)phenyl]guanidine::SMR000201560::cid_9567496

SMILES NC(Nc1ccccc1C(F)(F)F)=Nc1nc2CCCc2c(=O)[nH]1

InChI Key InChIKey=XFKHVPWQAXWFGS-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 72120   

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
Shanghai Hansoh Biomedical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 72120BDBM72120(N-(2-(1-(2-fluoroethyl)-1H-pyrazol-4-yl)pyrimidin-...)
Affinity DataIC50: 1.90nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRISMC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2026
Entry Details PCBioAssay
TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Shanghai Hansoh Biomedical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 72120BDBM72120(N-(2-(1-(2-fluoroethyl)-1H-pyrazol-4-yl)pyrimidin-...)
Affinity DataIC50: 8.90nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRISMC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2026
Entry Details PCBioAssay