BDBM721485 US20250059154, Compound 14

SMILES Cc1nc(-c2ccc(F)cc2-c2ccncc2C)c2c(n1)[C@]1(C)C=C(C#N)C(=O)[C@H](C)[C@H]1CC2

InChI Key InChIKey=IXMCAACDAITCOE-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 721485   

TargetNuclear receptor ROR-gamma [C345S](Human)
Reata Pharmaceuticals

US Patent
LigandPNGBDBM721485(US20250059154, Compound 14)
Affinity DataIC50: 33.9nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

US Patent
LigandPNGBDBM721485(US20250059154, Compound 14)
Affinity DataIC50: 35.7nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetNuclear receptor ROR-gamma [C320S](Human)
Reata Pharmaceuticals

US Patent
LigandPNGBDBM721485(US20250059154, Compound 14)
Affinity DataIC50: 36.7nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetNuclear receptor ROR-gamma [C455S](Human)
Reata Pharmaceuticals

US Patent
LigandPNGBDBM721485(US20250059154, Compound 14)
Affinity DataIC50: 37.5nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetNuclear receptor ROR-gamma [C285S](Human)
Reata Pharmaceuticals

US Patent
LigandPNGBDBM721485(US20250059154, Compound 14)
Affinity DataIC50: 37.6nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetNuclear receptor ROR-gamma [C366S](Human)
Reata Pharmaceuticals

US Patent
LigandPNGBDBM721485(US20250059154, Compound 14)
Affinity DataIC50: 39nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetNuclear receptor ROR-gamma [C278S](Human)
Reata Pharmaceuticals

US Patent
LigandPNGBDBM721485(US20250059154, Compound 14)
Affinity DataIC50: 41.3nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetNuclear receptor ROR-gamma [C320A](Human)
Reata Pharmaceuticals

US Patent
LigandPNGBDBM721485(US20250059154, Compound 14)
Affinity DataIC50: 43.7nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetNuclear receptor ROR-gamma [C393S](Human)
Reata Pharmaceuticals

US Patent
LigandPNGBDBM721485(US20250059154, Compound 14)
Affinity DataIC50: 60.4nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent