BDBM722554 (S)-N-(4-(4- amino-1-methyl- 7-(1-(tetrahydro- 2H-pyran-4- yl)-1H-pyrazol- 4-yl)-1H- pyrazolo[4,3-c] pyridin-3-yl)-2- (1-(4- fluorophenyl) ethoxy)phenyl) ethane- sulfonamide::US20250059188, Compound 45::US20250115598, Compound 45

SMILES CCS(=O)(=O)Nc1ccc(-c2nn(C)c3c(-c4cnn(C5CCOCC5)c4)cnc(N)c23)cc1O[C@@H](C)c1ccc(F)cc1

InChI Key InChIKey=OTOUGMOIAFUHHR-UHFFFAOYSA-N

Data  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 722554   

TargetMixed lineage kinase domain-like protein(Human)
Anaxis Pharma

US Patent
LigandPNGBDBM722554((S)-N-(4-(4- amino-1-methyl- 7-(1-(tetrahydro- 2H-...)
Affinity DataKd:  50.5nMAssay Description:For most assays, kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli wer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetMixed lineage kinase domain-like protein(Human)
Anaxis Pharma

US Patent
LigandPNGBDBM722554((S)-N-(4-(4- amino-1-methyl- 7-(1-(tetrahydro- 2H-...)
Affinity DataKd:  275nMAssay Description:Binding affinity of the test compounds for human MLKL (full length), mouse MLKL (full length), human RIPK1 and human RIPK3 was determined using the K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Anaxis Pharma

US Patent
LigandPNGBDBM722554((S)-N-(4-(4- amino-1-methyl- 7-(1-(tetrahydro- 2H-...)
Affinity DataKd:  1.50E+3nMAssay Description:Binding affinity of the test compounds for human MLKL (full length), mouse MLKL (full length), human RIPK1 and human RIPK3 was determined using the K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Anaxis Pharma

US Patent
LigandPNGBDBM722554((S)-N-(4-(4- amino-1-methyl- 7-(1-(tetrahydro- 2H-...)
Affinity DataKd: >2.50E+3nMAssay Description:Binding affinity of the test compounds for human MLKL (full length), mouse MLKL (full length), human RIPK1 and human RIPK3 was determined using the K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Anaxis Pharma

US Patent
LigandPNGBDBM722554((S)-N-(4-(4- amino-1-methyl- 7-(1-(tetrahydro- 2H-...)
Affinity DataKd: >1.00E+4nMAssay Description:For most assays, kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli wer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Anaxis Pharma

US Patent
LigandPNGBDBM722554((S)-N-(4-(4- amino-1-methyl- 7-(1-(tetrahydro- 2H-...)
Affinity DataKd: >1.00E+4nMAssay Description:For most assays, kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli wer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent