BDBM723289 US20250059220, Compound 401

SMILES NC(=O)c1cc(OCc2ccc(-c3cccnc3)cc2)c2sc(C(F)(F)P(=O)(O)O)c(Br)c2c1

InChI Key InChIKey=YEAQQCBAQBWTDA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 723289   

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 723289BDBM723289(US20250059220, Compound 401)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human PTPN2 using DiFMUP as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-type tyrosine-protein phosphatase N2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 723289BDBM723289(US20250059220, Compound 401)
Affinity DataIC50: 4.40nMAssay Description:Test compounds were dissolved in DMSO, and 10-point serial 3-fold dilution series in DMSO were prepared in Echo Qualified 384-well Polypropylene Micr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 723289BDBM723289(US20250059220, Compound 401)
Affinity DataIC50: 36nMAssay Description:Inhibition of PTP1B (unknown origin) using para-nitrophenol phosphate substrate incubated for 30 mins by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 723289BDBM723289(US20250059220, Compound 401)
Affinity DataIC50: 36.2nMAssay Description:Test compounds were dissolved in DMSO, and 10-point serial 3-fold dilution series in DMSO were prepared in Echo Qualified 384-well Polypropylene Micr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent