BDBM723368 (6-(4-fluoro-1H-pyrazol- 1-yl)pyridin-3-yl)(4-(4- methyl-6-((5-methyl-1H- pyrazol-3-yl)amino) pyrimidin-2-yl)piperazin-1-yl) methanone::US12234222, Compound I-1

SMILES Cc1cc(Nc2cc(C)[nH]n2)nc(N2CCN(C(=O)c3ccc(-n4cc(F)cn4)nc3)CC2)n1

InChI Key InChIKey=QXPSIKWWJZWWHB-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 723368   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandPNGBDBM723368((6-(4-fluoro-1H-pyrazol- 1-yl)pyridin-3-yl)(4-(4-...)
Affinity DataIC50: 12.5nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandPNGBDBM723368((6-(4-fluoro-1H-pyrazol- 1-yl)pyridin-3-yl)(4-(4-...)
Affinity DataIC50: 1.13E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent