BDBM723381 2-(8-(6-(4-fluoro-1H- pyrazol-1-yl)nicotinoyl)-3,8- diazabicyclo[3.2.1]octane- 3-yl)-6-(5-methyl-1H- pyrazol-3-yl)amino)pyrimidin- 4-formic acid::US12234222, Compound I-19

SMILES Cc1cc(Nc2cc(C(=O)O)nc(N3CC4CCC(C3)N4C(=O)c3ccc(-n4cc(F)cn4)nc3)n2)n[nH]1

InChI Key InChIKey=CXWCFAFQTKCPIP-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 723381   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandPNGBDBM723381(2-(8-(6-(4-fluoro-1H- pyrazol-1-yl)nicotinoyl)-3,...)
Affinity DataIC50: 25.6nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandPNGBDBM723381(2-(8-(6-(4-fluoro-1H- pyrazol-1-yl)nicotinoyl)-3,...)
Affinity DataIC50: 2.76E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent