BDBM724956 US12240825, Example 7

SMILES CC(=O)Nc1ccc(-n2nccn2)c(C(=O)N(C(C)C)[C@H]2CCC[C@@H]2COc2ccc(F)cc2)n1

InChI Key InChIKey=XESQBMMOMVMUNP-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 724956   

TargetOrexin/Hypocretin receptor type 1(Human)
Nxera Pharma UK

US Patent
LigandPNGBDBM724956(US12240825, Example 7)
Affinity DataKi:  7.94nMAssay Description:After thawing, membrane homogenates were resuspended in the binding buffer (8.5 mM HEPES, pH 7.4, 1.3 mM CaCl2, 1.2 mM MgSO4, 118 mM NaCl, 4.7 mM KCl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/4/2025
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Nxera Pharma UK

US Patent
LigandPNGBDBM724956(US12240825, Example 7)
Affinity DataKi: >5.01E+3nMAssay Description:After thawing, membrane homogenates were resuspended in the binding buffer (8.5 mM HEPES, pH 7.4, 1.3 mM CaCl2, 1.2 mM MgSO4, 118 mM NaCl, 4.7 mM KCl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/4/2025
Entry Details
US Patent