BDBM725162 (2''R,3R,4''R,5''S)—N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-4''-(3-chloro-2-fluorophenyl)-2''-(2,2-dimethylpropyl)-5''-methyl-1,2-dihydrospiro[indole-3,3''-pyrrolidine]-5''-carboxamide::US20250073340, Example 8

SMILES COc1cc(C(N)=O)ccc1NC(=O)[C@@]1(C)N[C@H](CC(C)(C)C)[C@]2(CNc3cc(Cl)ccc32)[C@@H]1c1cccc(Cl)c1F

InChI Key InChIKey=WBJKKMNFNMNHSH-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 725162   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Newave Pharmaceutical

US Patent
LigandPNGBDBM725162((2'R,3R,4'R,5'S)—N-(4-carbamoyl-2-methoxyphenyl)-6...)
Affinity DataIC50: 0.770nMAssay Description:The ability of the compounds to inhibit the interaction between p53 and MDM2 proteins was measured by an HTRF (homogeneous time-resolved fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2025
Entry Details
US Patent