BDBM725521 (R)-3-(4- ((difluoro- methyl)sulfon- amido)-3-(1-(4- fluorophenyl) ethoxy) phenyl)-5- (pyrazin-2- ylamino)-1H- pyrazole- 4-carboxamide::US20250074891, Compound 271

SMILES C[C@@H](Oc1cc(-c2n[nH]c(Nc3cnccn3)c2C(N)=O)ccc1NS(=O)(=O)C(F)F)c1ccc(F)cc1

InChI Key InChIKey=HVZZAKMDPAWLMH-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 725521   

TargetMixed lineage kinase domain-like protein(Human)
Anaxis Pharma

US Patent
LigandPNGBDBM725521((R)-3-(4- ((difluoro- methyl)sulfon- amido)-3-(1-(...)
Affinity DataKd: <10nMAssay Description:Kinase assays. For most assays, kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 stra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2025
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Anaxis Pharma

US Patent
LigandPNGBDBM725521((R)-3-(4- ((difluoro- methyl)sulfon- amido)-3-(1-(...)
Affinity DataKd: >3.00E+4nMAssay Description:Kinase assays. For most assays, kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 stra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2025
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Anaxis Pharma

US Patent
LigandPNGBDBM725521((R)-3-(4- ((difluoro- methyl)sulfon- amido)-3-(1-(...)
Affinity DataKd: >3.00E+4nMAssay Description:Kinase assays. For most assays, kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 stra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2025
Entry Details
US Patent