BDBM727133 US20250092017, Compound H18

SMILES CC(C)c1ccc(N2CC(CS(C)(=O)=O)C2)c2cnc(Nc3ccnc(-c4cnn(S(=O)(=O)C5(C)CC5)c4)n3)cc12

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 727133   

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
Suzhou Puhe Biopharma Co.

US Patent
LigandPNGBDBM727133(US20250092017, Compound H18)
Affinity DataIC50: 0.600nMAssay Description:The MSA (Mobility Shift Assay) method was used to detect the effects of small molecule inhibitors on the kinase activity of EGFR wild type and its mu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Suzhou Puhe Biopharma Co.

US Patent
LigandPNGBDBM727133(US20250092017, Compound H18)
Affinity DataIC50: 2.60nMAssay Description:The MSA (Mobility Shift Assay) method was used to detect the effects of small molecule inhibitors on the kinase activity of EGFR wild type and its mu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R,C797S](Human)
Suzhou Puhe Biopharma Co.

US Patent
LigandPNGBDBM727133(US20250092017, Compound H18)
Affinity DataIC50: 5nMAssay Description:The MSA (Mobility Shift Assay) method was used to detect the effects of small molecule inhibitors on the kinase activity of EGFR wild type and its mu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Suzhou Puhe Biopharma Co.

US Patent
LigandPNGBDBM727133(US20250092017, Compound H18)
Affinity DataIC50: 7.30nMAssay Description:The MSA (Mobility Shift Assay) method was used to detect the effects of small molecule inhibitors on the kinase activity of EGFR wild type and its mu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent