BDBM729456 Preparation of 5-Cyclobutyl-N-[4-(2-Fluorophenyl)-5-(3-Fluoropyridin-4-Yl)-1,3-Thiazol-2-Yl]-1H-1,2,4-Triazol-3-Amine ::US20250101013, Compound 1

SMILES Fc1ccccc1-c1nc(NC2=NCC(C3CCC3)=N2)sc1-c1ccncc1F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 729456   

TargetAdenosine receptor A2b(Human)
Leadxpro

US Patent
LigandPNGBDBM729456(Preparation of 5-Cyclobutyl-N-[4-(2-Fluorophenyl)-...)
Affinity DataEC50:  2.20nMAssay Description:In all radioligand binding experiments, the samples were incubated in a final volume of 0.1 ml of binding buffer for 60 minutes at 25° C. and then fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent

TargetAdenosine receptor A1(Human)
Leadxpro

US Patent
LigandPNGBDBM729456(Preparation of 5-Cyclobutyl-N-[4-(2-Fluorophenyl)-...)
Affinity DataEC50: <5nMAssay Description:In all radioligand binding experiments, the samples were incubated in a final volume of 0.1 ml of binding buffer for 60 minutes at 25° C. and then fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent

TargetAdenosine receptor A2a(Human)
Leadxpro

US Patent
LigandPNGBDBM729456(Preparation of 5-Cyclobutyl-N-[4-(2-Fluorophenyl)-...)
Affinity DataEC50: >1.00E+4nMAssay Description:In all radioligand binding experiments, the samples were incubated in a final volume of 0.1 ml of binding buffer for 60 minutes at 25° C. and then fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent

TargetAdenosine receptor A3(Human)
Leadxpro

US Patent
LigandPNGBDBM729456(Preparation of 5-Cyclobutyl-N-[4-(2-Fluorophenyl)-...)
Affinity DataEC50: >1.00E+4nMAssay Description:In all radioligand binding experiments, the samples were incubated in a final volume of 0.1 ml of binding buffer for 60 minutes at 25° C. and then fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent