BDBM729749 US20250101040, Compound M3

SMILES Cc1nn(-c2cccnc2)c(C)c1-c1cc(N2CC3CCC(C2)O3)nc2c(-c3ccn[nH]3)cnn12

InChI Key InChIKey=UAZUSSYGOQZXRK-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 729749   

TargetSerine/threonine-protein kinase ATR(Human)
Jiangsu Yayo Biotechnology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 729749BDBM729749(US20250101040, Compound M3)
Affinity DataIC50: 7nMAssay Description:The amount of phosphorylated P53 protein was determined using a time-resolved fluorescence system. Before the starting of the experiment, the followi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
Jiangsu Yayo Biotechnology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 729749BDBM729749(US20250101040, Compound M3)
Affinity DataIC50: 8nMAssay Description:Inhibition of ATR (unknown origin) assessed as reduction in p53 phosphorylation level incubated for 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Jiangsu Yayo Biotechnology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 729749BDBM729749(US20250101040, Compound M3)
Affinity DataIC50: 180nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Chinese Academy of Medical Sciences & Peking Union Medical College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 729749BDBM729749(US20250101040, Compound M3)
Affinity DataIC50: 1.82E+3nMAssay Description:Inhibition of mTOR (unknown origin) preincubated for 15 mins and measured after 60 mins by Z-LYTE screeningMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Chinese Academy of Medical Sciences & Peking Union Medical College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 729749BDBM729749(US20250101040, Compound M3)
Affinity DataIC50: 3.58E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) preincubated for 15 mins and measured after 60 mins by by Z-LYTE screeningMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine-protein kinase ATM(Human)
Jiangsu Yayo Biotechnology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 729749BDBM729749(US20250101040, Compound M3)
Affinity DataIC50: 1.00E+4nMAssay Description:Following the experimental methods reported in the reference documents, the test compounds were diluted in a 3-fold series to 0.51 nM (a total of 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent

TargetSerine-protein kinase ATM(Human)
Jiangsu Yayo Biotechnology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 729749BDBM729749(US20250101040, Compound M3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ATM (unknown origin) preincubated for 15 mins and measured after 60 mins by Z-LYTE screeningMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed