BDBM730888 US20250122183, Example 101

SMILES CCOc1cc(C(F)F)ccc1S(=O)(=O)Nc1noc2cc(Nc3cc(C4CC4)n[nH]3)c(F)c(OC)c12

InChI Key InChIKey=UIFWOLQLQIOEBG-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 730888   

TargetHistone acetyltransferase KAT6A(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 730888BDBM730888(US20250122183, Example 101)
Affinity DataKi:  5.30nMAssay Description:1. Final reaction conditions are 2.5 nM KAT6A Full length enzyme, 25 μM AcCoA,2 μM H3 1-21 peptide, in a 20 μL reaction volume.2. Add 200 nL of dilut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 730888BDBM730888(US20250122183, Example 101)
Affinity DataKi:  50.7nMAssay Description:1. Final reaction conditions are 4 nM KAT7+JADE1+EAF6+ING5 4-protein complex, 1 μM AcCoA, 2 μM H3 1-21 peptide, in a 20 μL reaction volume.2. Add 200...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

TargetHistone acetyltransferase KAT5(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 730888BDBM730888(US20250122183, Example 101)
Affinity DataKi:  1.23E+3nMAssay Description:1. Final reaction conditions are 12.5 nM KAT5 Full length enzyme, 1 μM AcCoA, 2 μM H4 1-21 peptide, in a 20 μL reaction volume.2. Add 200 nL of dilut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

TargetHistone acetyltransferase KAT8(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 730888BDBM730888(US20250122183, Example 101)
Affinity DataKi:  1.03E+4nMAssay Description:1. Final reaction conditions are 30 nM KAT8 Full length enzyme, 1 μM AcCoA, 2 μM H3 1-21 peptide, in a 20 μL reaction volume.2. Add 200 nL of diluted...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent