BDBM730976 (stereospecific procedure): N-{6-[(3-cyclopropyl-1 H-pyrazol-5-yl)amino]-5-methoxy-1,2-benzoxazol-3-yl}-2,6-dimethoxy-4-[(2S)-1-methylpyrrolidin-2-yl]benzene-1-sulfonamide::US20250122183, Example 189

SMILES COc1ccc(CN(c2noc3cc(Nc4cc(C5CC5)n[nH]4)c(OC)cc23)S(=O)(=O)c2c(OC)cc([C@@H]3CCCN3C(=O)OC(C)(C)C)cc2OC)cc1

InChI Key InChIKey=JOUJVRJBPAKRKI-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 730976   

TargetHistone acetyltransferase KAT6A(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 730976BDBM730976((stereospecific procedure): N-{6-[(3-cyclopropyl-1...)
Affinity DataKi:  3.70nMAssay Description:1. Final reaction conditions are 2.5 nM KAT6A Full length enzyme, 25 μM AcCoA,2 μM H3 1-21 peptide, in a 20 μL reaction volume.2. Add 200 nL of dilut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 730976BDBM730976((stereospecific procedure): N-{6-[(3-cyclopropyl-1...)
Affinity DataKi:  20.8nMAssay Description:1. Final reaction conditions are 4 nM KAT7+JADE1+EAF6+ING5 4-protein complex, 1 μM AcCoA, 2 μM H3 1-21 peptide, in a 20 μL reaction volume.2. Add 200...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent