BDBM731018 US20250122183, Example 231

SMILES CCc1cc(Nc2cc3onc(NS(=O)(=O)c4c(OC)cc(-c5cccc(C)n5)cc4OC)c3cc2OC)[nH]n1

InChI Key InChIKey=WHCKBGGSKRNSEN-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 731018   

TargetHistone acetyltransferase KAT6A(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 731018BDBM731018(US20250122183, Example 231)
Affinity DataKi:  1.10nMAssay Description:1. Final reaction conditions are 2.5 nM KAT6A Full length enzyme, 25 μM AcCoA,2 μM H3 1-21 peptide, in a 20 μL reaction volume.2. Add 200 nL of dilut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 731018BDBM731018(US20250122183, Example 231)
Affinity DataKi:  8.80nMAssay Description:1. Final reaction conditions are 4 nM KAT7+JADE1+EAF6+ING5 4-protein complex, 1 μM AcCoA, 2 μM H3 1-21 peptide, in a 20 μL reaction volume.2. Add 200...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

TargetHistone acetyltransferase KAT8(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 731018BDBM731018(US20250122183, Example 231)
Affinity DataKi:  859nMAssay Description:1. Final reaction conditions are 30 nM KAT8 Full length enzyme, 1 μM AcCoA, 2 μM H3 1-21 peptide, in a 20 μL reaction volume.2. Add 200 nL of diluted...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent