BDBM731025 US20250122183, Example 238

SMILES CCc1cc(Nc2cc3onc(NS(=O)(=O)c4c(OC)cc(-c5cn(C)cn5)cc4OC)c3cc2OC)[nH]n1

InChI Key InChIKey=PETFNMXWGFCTTO-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 731025   

TargetHistone acetyltransferase KAT6A(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 731025BDBM731025(US20250122183, Example 238)
Affinity DataKi:  1.20nMAssay Description:1. Final reaction conditions are 2.5 nM KAT6A Full length enzyme, 25 μM AcCoA,2 μM H3 1-21 peptide, in a 20 μL reaction volume.2. Add 200 nL of dilut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 731025BDBM731025(US20250122183, Example 238)
Affinity DataKi:  12.7nMAssay Description:1. Final reaction conditions are 4 nM KAT7+JADE1+EAF6+ING5 4-protein complex, 1 μM AcCoA, 2 μM H3 1-21 peptide, in a 20 μL reaction volume.2. Add 200...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent