BDBM732837 6-(((1S,2S,4S)-4-(3,4-dichloro- phenyl)-2-(dimethylamino)- cyclohexyl)oxy)-2-methyl-N- (pyrimidin-4-yl)pyridine-3- sulfonamide::US20250115576, Example 37

SMILES Cc1nc(O[C@H]2CC[C@H](c3ccc(Cl)c(Cl)c3)C[C@@H]2N(C)C)ccc1S(=O)(=O)Nc1ccncn1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 732837   

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM732837(6-(((1S,2S,4S)-4-(3,4-dichloro- phenyl)-2-(dimethy...)
Affinity DataIC50: 0.301nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM732837(6-(((1S,2S,4S)-4-(3,4-dichloro- phenyl)-2-(dimethy...)
Affinity DataIC50: 1.36nMAssay Description:A competitive NaV1.7 inhibitor having a methyl group is tritiated. Three tritiums are incorporated in place of methyl hydrogens to generate [3H]compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent