BDBM7333 14-nitro-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octadeca-1(11),2,4,6,12(17),13,15-heptaene-9-thione::9-Nitro-7,12-dihydro-indolo[3,2-d][1]benzazepine-6(5H)-thione::NSC 716452::Paullone Analogue 68

SMILES [O-][N+](=O)c1ccc2[nH]c-3c(CC(=S)Nc4ccccc-34)c2c1

InChI Key InChIKey=AVIIETUEUKVYCP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 7333   

TargetGlycogen synthase kinase-3 beta(Rat)
Universitat Hamburg

LigandPNGBDBM7333(9-Nitro-7,12-dihydro-indolo[3,2-d][1]benzazepine-6...)
Affinity DataIC50: 600nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Universitat Hamburg

LigandPNGBDBM7333(9-Nitro-7,12-dihydro-indolo[3,2-d][1]benzazepine-6...)
Affinity DataIC50: 1.30E+3nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Human)
Universitat Hamburg

LigandPNGBDBM7333(9-Nitro-7,12-dihydro-indolo[3,2-d][1]benzazepine-6...)
Affinity DataIC50: 1.70E+3nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2006
Entry Details Article
PubMed