BDBM736439 4-((1H-pyrazol-1-yl)methyl)- N-((5-(tert-butyl)-2- methoxyphenyl)sulfonyl)- 3-methylbenzamide::US20250136553, Compound 20::US20250304535, Example C3

SMILES COc1ccc(C(C)(C)C)cc1S(=O)(=O)NC(=O)c1ccc(Cn2cccn2)c(C)c1

InChI Key InChIKey=MRMZNYJXFVGRQJ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 736439   

TargetHistone acetyltransferase KAT6A(Human)
Olema Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 736439BDBM736439(4-((1H-pyrazol-1-yl)methyl)- N-((5-(tert-butyl)-2-...)
Affinity DataIC50: 39nMAssay Description:TR-FRET based methods were used for assaying compounds of the present invention for KAT6A enzyme inhibitory activity. TR-FRET is a homogeneous proxim...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2025
Entry Details
US Patent

TargetHistone acetyltransferase KAT6B [657-1069](Human)
Beigene Switzerland

US Patent
LigandChemical structure of BindingDB Monomer ID 736439BDBM736439(4-((1H-pyrazol-1-yl)methyl)- N-((5-(tert-butyl)-2-...)
Affinity DataIC50: 100nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone acetyltransferase KAT6A [497-780](Human)
Beigene Switzerland

US Patent
LigandChemical structure of BindingDB Monomer ID 736439BDBM736439(4-((1H-pyrazol-1-yl)methyl)- N-((5-(tert-butyl)-2-...)
Affinity DataIC50: 100nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent