BDBM736491 5-((1H-pyrazol-1-yl)methyl)-N-((2,6- dimethoxyphenyl)sulfonyl)-6-methoxypicolinamide::US20250136553, Compound 203::US20250304535, Example C69

SMILES COc1cccc(OC)c1S(=O)(=O)NC(=O)c1ccc(Cn2cccn2)c(OC)n1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 736491   

TargetHistone acetyltransferase KAT6A(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM736491(5-((1H-pyrazol-1-yl)methyl)-N-((2,6- dimethoxyphen...)
Affinity DataIC50: 9nMAssay Description:TR-FRET based methods were used for assaying compounds of the present invention for KAT6A enzyme inhibitory activity. TR-FRET is a homogeneous proxim...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2025
Entry Details
US Patent

TargetHistone acetyltransferase KAT6A [497-780](Human)
Beigene Switzerland

US Patent
LigandPNGBDBM736491(5-((1H-pyrazol-1-yl)methyl)-N-((2,6- dimethoxyphen...)
Affinity DataIC50: 100nMAssay Description:Testing for the inhibition activities of various compounds disclosed herein was carried out at room temperature in assay buffer containing 100 mM Tri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone acetyltransferase KAT6B [657-1069](Human)
Beigene Switzerland

US Patent
LigandPNGBDBM736491(5-((1H-pyrazol-1-yl)methyl)-N-((2,6- dimethoxyphen...)
Affinity DataIC50: 100nMAssay Description:Testing for the inhibition activities of various compounds disclosed herein was carried out at room temperature in assay buffer containing 100 mM Tri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent