BDBM736849 7-(6-((1-(4-(Difluoromethyl)phenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)pyridazin-3-yl)-4,7-diazaspiro[2.5]octan-5-one ::US20250136581, Example 8

SMILES Cc1nnn(-c2ccc(C(F)F)cc2)c1COc1ccc(N2CC(=O)NC3(CC3)C2)nn1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 736849   

TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
Shanghai Simr Biotechnology

US Patent
LigandPNGBDBM736849(7-(6-((1-(4-(Difluoromethyl)phenyl)-4-methyl-1H-1,...)
Affinity DataKi:  0.890nMAssay Description:The affinity of the compound to each subtype of GABAA receptor was determined by competing for the binding of 3H-flunitrazepam to HEK293 cells stably...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Shanghai Simr Biotechnology

US Patent
LigandPNGBDBM736849(7-(6-((1-(4-(Difluoromethyl)phenyl)-4-methyl-1H-1,...)
Affinity DataKi:  17nMAssay Description:The affinity of the compound to each subtype of GABAA receptor was determined by competing for the binding of 3H-flunitrazepam to HEK293 cells stably...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2025
Entry Details
US Patent

TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Shanghai Simr Biotechnology

US Patent
LigandPNGBDBM736849(7-(6-((1-(4-(Difluoromethyl)phenyl)-4-methyl-1H-1,...)
Affinity DataKi:  22.2nMAssay Description:The affinity of the compound to each subtype of GABAA receptor was determined by competing for the binding of 3H-flunitrazepam to HEK293 cells stably...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
Shanghai Simr Biotechnology

US Patent
LigandPNGBDBM736849(7-(6-((1-(4-(Difluoromethyl)phenyl)-4-methyl-1H-1,...)
Affinity DataKi:  80.5nMAssay Description:The affinity of the compound to each subtype of GABAA receptor was determined by competing for the binding of 3H-flunitrazepam to HEK293 cells stably...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2025
Entry Details
US Patent