BDBM738222 Preparation of N-(5-(4-(2-acryloyl-2,7-diazaspiro[3.5]nonan-7-yl)quinazolin-6-yl)-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide::US20250145589, Example 18

SMILES C=CC(=O)N1CC2(CCN(c3ncnc4ccc(-c5cnc(OC)c(NS(=O)(=O)c6ccc(F)cc6F)c5)cc34)CC2)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 738222   

LigandPNGBDBM738222(Preparation of N-(5-(4-(2-acryloyl-2,7-diazaspiro[...)
Affinity DataIC50: 1.20nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kα with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

LigandPNGBDBM738222(Preparation of N-(5-(4-(2-acryloyl-2,7-diazaspiro[...)
Affinity DataIC50: 12.5nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kδ with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent