BDBM738415 (E)-3-fluoro-N- (2-methoxy-5- (4-(4-(4- oxopent- 2-enoyl) piperazin-1-yl) pyrido[3,2-d] pyrimidin-6-yl) pyridin-3-yl) pyridine-4- sulfonamide::US20250145589, Example 220

SMILES COc1ncc(-c2ccc3ncnc(N4CCN(C(=O)/C=C/C(C)=O)CC4)c3n2)cc1NS(=O)(=O)c1ccncc1F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 738415   

LigandPNGBDBM738415((E)-3-fluoro-N- (2-methoxy-5- (4-(4-(4- oxopent- 2...)
Affinity DataIC50: 1.10nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kα with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

LigandPNGBDBM738415((E)-3-fluoro-N- (2-methoxy-5- (4-(4-(4- oxopent- 2...)
Affinity DataIC50: 11.4nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kδ with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandPNGBDBM738415((E)-3-fluoro-N- (2-methoxy-5- (4-(4-(4- oxopent- 2...)
Affinity DataIC50: 274nMAssay Description:The HTRF KRASG12C/SOS1 Binding Assay was used to measure the interaction between KRASG12C and SOS1 proteins, and evaluate the enzymatic activity of c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent