BDBM739713 (E)-1-((2S,5R)-5-((5-((R)-2,2-difluorocyclopropyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2- methylpiperidin-1-yl)-4-(dimethylamino)but-2-en-1- one::US12297203, Example 60

SMILES C[C@H]1CC[C@@H](Nc2ncnc3[nH]cc([C@H]4CC4(F)F)c23)CN1C(=O)/C=C/CN(C)C

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 739713   

TargetTyrosine-protein kinase JAK3(Human)
Aclaris Therapeutics

US Patent
LigandPNGBDBM739713((E)-1-((2S,5R)-5-((5-((R)-2,2-difluorocyclopropyl)...)
Affinity DataIC50: 10nMAssay Description:The ability of candidate compounds to interact with JAK3 is quantitated by a mobility shift assay using an LC3000 instrument developed by Caliper Lif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/11/2025
Entry Details
US Patent