BDBM739730 1-((R)-3-((5-((1S,5R)-6,6-difluorobicyclo[3.1.0]hexan- 1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl)amino)piperidin-1-yl)prop-2-en-1-one::US12297203, Example 80

SMILES C=CC(=O)N1CCC[C@@H](Nc2ncnc3[nH]cc([C@]45CCC[C@H]4C5(F)F)c23)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 739730   

TargetTyrosine-protein kinase JAK3(Human)
Aclaris Therapeutics

US Patent
LigandPNGBDBM739730(1-((R)-3-((5-((1S,5R)-6,6-difluorobicyclo[3.1.0]he...)
Affinity DataIC50: 10nMAssay Description:The ability of candidate compounds to interact with JAK3 is quantitated by a mobility shift assay using an LC3000 instrument developed by Caliper Lif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/11/2025
Entry Details
US Patent