BDBM740587 1-methyl-4-[[rac-(1R)-1-[3- (trifluoromethyl)phenyl]ethyl]amino]-6- tetrahydrofuran-3-yl-pyrido[3,4- d]pyridazin-7-one::US20250154147, Example 8

SMILES Cc3nnc(N[C@H](C)c1cccc(C(F)(F)F)c1)c4cn(C2CCOC2)c(=O)cc34

InChI Key

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 740587   

TargetGTPase KRas/Son of sevenless homolog 1 [564-1049](Human)
Jazz Pharmaceuticals Ireland

US Patent
LigandPNGBDBM740587(1-methyl-4-[[rac-(1R)-1-[3- (trifluoromethyl)pheny...)
Affinity DataIC50: 234nMAssay Description:The capacity of compounds to inhibit SOS1 binding to KRAS-WT (wild-type) was quantified using a FRET-based protein-protein interaction assay. The ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/16/2025
Entry Details
US Patent