BDBM740595 1,8-dimethyl-3-(1,2,3,6- tetrahydropyridin-5-yl)-5-[[(1R)-1-[3- (trifluoromethyl)phenyl]ethyl]amino] pyrido[2,3-d]pyridazin-2-one::US20250154147, Example 16

SMILES Cc3nnc(N[C@H](C)c1cccc(C(F)(F)F)c1)c4cc(C2=CCCNC2)c(=O)n(C)c34

InChI Key

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 740595   

TargetGTPase KRas/Son of sevenless homolog 1 [564-1049](Human)
Jazz Pharmaceuticals Ireland

US Patent
LigandPNGBDBM740595(1,8-dimethyl-3-(1,2,3,6- tetrahydropyridin-5-yl)-5...)
Affinity DataIC50: 50.1nMAssay Description:The capacity of compounds to inhibit SOS1 binding to KRAS-WT (wild-type) was quantified using a FRET-based protein-protein interaction assay. The ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Date in BDB:
9/16/2025
Entry Details
US Patent