BDBM740602 5-[[(1R)-1-[2-fluoro-3- (trifluoromethyl)phenyl]ethyl]amino]-1,8- dimethyl-3-(4-piperidyl)pyrido[2,3- d]pyridazin-2-one::US20250154147, Example 23

SMILES Cc3nnc(N[C@H](C)c1cccc(C(F)(F)F)c1F)c4cc(C2CCNCC2)c(=O)n(C)c34

InChI Key

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 740602   

TargetGTPase KRas/Son of sevenless homolog 1 [564-1049](Human)
Jazz Pharmaceuticals Ireland

US Patent
LigandPNGBDBM740602(5-[[(1R)-1-[2-fluoro-3- (trifluoromethyl)phenyl]et...)
Affinity DataIC50: 57.5nMAssay Description:The capacity of compounds to inhibit SOS1 binding to KRAS-WT (wild-type) was quantified using a FRET-based protein-protein interaction assay. The ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Date in BDB:
9/16/2025
Entry Details
US Patent