BDBM741619 N-hydroxy-4-((4-((((1S,2R)-2-phenylcyclopropyl)amino)methyl)-1H-pyrazol-1-yl)methyl)benzamide::US20250162994, Example 2

SMILES O=C(NO)c1ccc(Cn2cc(CN[C@H]3CC3c3ccccc3)cn2)cc1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 741619   

TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM741619(N-hydroxy-4-((4-((((1S,2R)-2-phenylcyclopropyl)ami...)
Affinity DataIC50: 178nMAssay Description:Histone deacetylase assay was done as per manufacturer's instructions. Briefly, assay buffer, 200 uM HDAC substrate (fluorogenic HDAC acetylated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM741619(N-hydroxy-4-((4-((((1S,2R)-2-phenylcyclopropyl)ami...)
Affinity DataIC50: 1.34E+3nMAssay Description:LSD1 enzyme was produced in house. Tranylcypromine (TCP), LSD1 inhibitor was procured from Selleckchem. LSD1 enzyme, TCP and Biotinylated peptide sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetHistone deacetylase 1(Human)TBA
LigandPNGBDBM741619(N-hydroxy-4-((4-((((1S,2R)-2-phenylcyclopropyl)ami...)
Affinity DataIC50: 1.55E+3nMAssay Description:Histone deacetylase assay was done as per manufacturer's instructions. Briefly, assay buffer, 200 uM HDAC substrate (fluorogenic HDAC acetylated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent