BDBM743682 5-(4-((1-(5-chloro-4-((1- methyl-2-oxo-3-(((S)-3- oxobutan-2-yl)oxy)-1,2- dihydroquinolin-6- yl)amino)pyrimidin-2- yl)piperidin-4- yl)methyl)piperazin-1- yl)-2-((S)-2,6- dioxopiperidin-3- yl)isoindoline-1,3-dione::US12310975, Example 217

SMILES CC(=O)[C@H](C)Oc1cc2cc(Nc3nc(N4CCC(CN5CCN(c6ccc7c(c6)C(=O)N([C@H]6CCC(=O)NC6=O)C7=O)CC5)CC4)ncc3Cl)ccc2n(C)c1=O

InChI Key InChIKey=ODTCWBBSJVFWAH-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 743682   

TargetB-cell lymphoma 6 protein(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 743682BDBM743682(5-(4-((1-(5-chloro-4-((1- methyl-2-oxo-3-(((S)-3- ...)
Affinity DataIC50: 100nMAssay Description:Assay buffer A: 50 mM HEPES pH 7.5, 125 mM NaCl, 0.01% TritonX.Assay buffer B (made fresh): buffer A+1 mM Glutathione (or 0.5 mM DTT).Assay buffer C ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2025
Entry Details
US Patent