BDBM743708 4-(4-((4-(5-chloro-4-((1- methyl-3-(2- (methylamino)-2- oxoethoxy)-2-oxo-1,2- dihydroquinolin-6- yl)amino)pyrimidin-2- yl)piperazin-1- yl)methyl)piperidin-1-yl)- N-(2,6-dioxopiperidin-3- yl)-2-methoxybenzamide::US12310975, Example 243

SMILES CNC(=O)COc1cc2cc(Nc3nc(N4CCN(CC5CCN(c6ccc(C(=O)NC7CCC(=O)NC7=O)c(OC)c6)CC5)CC4)ncc3Cl)ccc2n(C)c1=O

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 743708   

TargetB-cell lymphoma 6 protein(Human)
Arvinas Operations

US Patent
LigandPNGBDBM743708(4-(4-((4-(5-chloro-4-((1- methyl-3-(2- (methylamin...)
Affinity DataIC50: 10nMAssay Description:Assay buffer A: 50 mM HEPES pH 7.5, 125 mM NaCl, 0.01% TritonX.Assay buffer B (made fresh): buffer A+1 mM Glutathione (or 0.5 mM DTT).Assay buffer C ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2025
Entry Details
US Patent