BDBM743748 3-[7-({5-chloro-2-[4-(2- {1-[2-(2,6- dioxopiperidin-3-yl)-1,3- dioxo-2,3-dihydro-1H- isoindol-5-yl]piperidin-4- yl}propan-2-yl)piperazin- 1-yl]pyrimidin-4- yl}amino)-4-methyl-3- oxo-3,4-dihydro-2H-1,4- benzoxazin-2-yl]-N- methylpropanamide::US12310975, Example 287

SMILES CNC(=O)CCC1Oc2cc(Nc3nc(N4CCN(C(C)(C)C5CCN(c6ccc7c(c6)C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CC4)ncc3Cl)ccc2N(C)C1=O

InChI Key InChIKey=GVQGKMJIZDUMIQ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 743748   

TargetB-cell lymphoma 6 protein(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 743748BDBM743748(3-[7-({5-chloro-2-[4-(2- {1-[2-(2,6- dioxopiperidi...)
Affinity DataIC50: 100nMAssay Description:Assay buffer A: 50 mM HEPES pH 7.5, 125 mM NaCl, 0.01% TritonX.Assay buffer B (made fresh): buffer A+1 mM Glutathione (or 0.5 mM DTT).Assay buffer C ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2025
Entry Details
US Patent