BDBM743813 3-(4-{[(2R,6S)-4-[5- chloro-4-({1-methyl-3- [(methylcarbamoyl) methoxy]-2-oxo-1,2- dihydroquinolin-6- yl}amino)pyrimidin-2- yl]-2,6- dimethylpiperazin-1- yl]methyl}piperidin-1- yl)-N-(2,6- dioxopiperidin-3-yl)-2- fluorobenzamide::US12310975, Example 355

SMILES CNC(=O)COc1cc2cc(Nc3nc(N4C[C@@H](C)N(CC5CCN(c6cccc(C(=O)NC7CCC(=O)NC7=O)c6F)CC5)[C@@H](C)C4)ncc3Cl)ccc2n(C)c1=O

InChI Key InChIKey=DORUQPFXAXHNMO-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 743813   

TargetB-cell lymphoma 6 protein(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 743813BDBM743813(3-(4-{[(2R,6S)-4-[5- chloro-4-({1-methyl-3- [(meth...)
Affinity DataIC50: 75nMAssay Description:Assay buffer A: 50 mM HEPES pH 7.5, 125 mM NaCl, 0.01% TritonX.Assay buffer B (made fresh): buffer A+1 mM Glutathione (or 0.5 mM DTT).Assay buffer C ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2025
Entry Details
US Patent