BDBM743839 rac-2-[(6-{[5-chloro-2-(4- {[(2R,6S)-4-[2-(2,6- dioxopiperidin-3-yl)-1,3- dioxo-2,3-dihydro-1H- isoindol-4-yl]-2,6- dimethylpiperazin-1- yl]methyl}piperidin-1- yl)pyrimidin-4- yl]amino}-2-oxo-1- (propan-2-yl)-1,2- dihydroquinolin-3- yl)oxy]-N- methylacetamide::US12310975, Example 381

SMILES CNC(=O)COc1cc2cc(Nc3nc(N4CCC(CN5[C@H](C)CN(c6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)C[C@@H]5C)CC4)ncc3Cl)ccc2n(C(C)C)c1=O

InChI Key InChIKey=GVBDMPMHWQMAKP-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 743839   

TargetB-cell lymphoma 6 protein(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 743839BDBM743839(rac-2-[(6-{[5-chloro-2-(4- {[(2R,6S)-4-[2-(2,6- di...)
Affinity DataIC50: 10nMAssay Description:Assay buffer A: 50 mM HEPES pH 7.5, 125 mM NaCl, 0.01% TritonX.Assay buffer B (made fresh): buffer A+1 mM Glutathione (or 0.5 mM DTT).Assay buffer C ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2025
Entry Details
US Patent