BDBM743840 2-{[6-({5-chloro-2- [(2S,6R)-2-({[2-(2,6- dioxopiperidin-3-yl)-1,3- dioxo-2,3-dihydro-1H- isoindol-5- yl]oxy}methyl)-6- methylmorpholin-4- yl]pyrimidin-4- yl}amino)-2-oxo-1-::US12310975, Example 382

SMILES CNC(=O)COc1cc2cc(Nc3nc(N4C[C@@H](COc5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)O[C@H](C)C4)ncc3Cl)ccc2n(C(C)C)c1=O

InChI Key InChIKey=TYSHELSPMGBLFY-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 743840   

TargetB-cell lymphoma 6 protein(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 743840BDBM743840(2-{[6-({5-chloro-2- [(2S,6R)-2-({[2-(2,6- dioxopip...)
Affinity DataIC50: 75nMAssay Description:Assay buffer A: 50 mM HEPES pH 7.5, 125 mM NaCl, 0.01% TritonX.Assay buffer B (made fresh): buffer A+1 mM Glutathione (or 0.5 mM DTT).Assay buffer C ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2025
Entry Details
US Patent