BDBM743847 2-{[6-({5-chloro-2- [(2S,6R)-2-({[2-(2,6- dioxopiperidin-3-yl)-1,3- dioxo-2,3-dihydro-1H- isoindol-5- yl]oxy}methyl)-6- ethylmorpholin-4- yl]pyrimidin-4- yl}amino)-2-oxo-1- (propan-2-yl)-1,2-::US12310975, Example 389

SMILES CC[C@@H]1CN(c2ncc(Cl)c(Nc3ccc4c(c3)cc(OCC(=O)NC)c(=O)n4C(C)C)n2)C[C@@H](COc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)O1

InChI Key InChIKey=RUXQKAMJQJUFLM-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 743847   

TargetB-cell lymphoma 6 protein(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 743847BDBM743847(2-{[6-({5-chloro-2- [(2S,6R)-2-({[2-(2,6- dioxopip...)
Affinity DataIC50: 30nMAssay Description:Assay buffer A: 50 mM HEPES pH 7.5, 125 mM NaCl, 0.01% TritonX.Assay buffer B (made fresh): buffer A+1 mM Glutathione (or 0.5 mM DTT).Assay buffer C ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2025
Entry Details
US Patent