BDBM743897 2-{[6-({5-chloro-2-[2- ({1-[2-(2,6- dioxopiperidin-3-yl)-1- oxo-2,3-dihydro-1H- isoindol-4-yl]piperidin-4- yl}methyl)-2,7- diazaspiro[3.5]nonan-7- yl]pyrimidin-4- yl}amino)-2-oxo-1- (propan-2-yl)-1,2- dihydroquinolin-3- yl]oxy}-N- methylacetamide::US12310975, Example 443

SMILES CNC(=O)COc1cc2cc(Nc3nc(N4CCC5(CC4)CN(CC4CCN(c6cccc7c6CN(C6CCC(=O)NC6=O)C7=O)CC4)C5)ncc3Cl)ccc2n(C(C)C)c1=O

InChI Key InChIKey=KAXSYIUSJOVCSS-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 743897   

TargetB-cell lymphoma 6 protein(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 743897BDBM743897(2-{[6-({5-chloro-2-[2- ({1-[2-(2,6- dioxopiperidin...)
Affinity DataIC50: 10nMAssay Description:Assay buffer A: 50 mM HEPES pH 7.5, 125 mM NaCl, 0.01% TritonX.Assay buffer B (made fresh): buffer A+1 mM Glutathione (or 0.5 mM DTT).Assay buffer C ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2025
Entry Details
US Patent