BDBM745535 US12319655, Example 14

SMILES CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)cc(C3CC3)n2)ccn1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 745535   

TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM745535(US12319655, Example 14)
Affinity DataIC50: 100nMAssay Description:Activity of B-Raf (V600E) (SEQ. ID NO: 4) kinase was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrogenase assay that co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/25/2025
Entry Details
US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D](Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM745535(US12319655, Example 14)
Affinity DataIC50: 100nMAssay Description:Activity of C-Raf kinase (SEQ. ID NO: 3) was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrogenase assay that continuous...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [416-766](Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM745535(US12319655, Example 14)
Affinity DataIC50: 100nMAssay Description:Activity of B-Raf kinase (SEQ. ID NO: 2) was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrogenase assay that continuous...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D](Homo sapiens (Human))
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM745535(US12319655, Example 14)
Affinity DataIC50: 5.50E+3nMAssay Description:Activity of A-Raf kinase (SEQ. ID No: 1) was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrogenase assay that continuous...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/25/2025
Entry Details
US Patent