BDBM746184 (3R4R or 3S,4S)-4-(4-(5-chloro-1-(1-(3-methoxybicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl)-1H-indazol-6-yl)piperazin-1-yl)-4-methyltetrahydrofuran-3-ol and (3S,4S or 3R,4R)-4-(4-(5-chloro-1-(1-(3-methoxybicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl)-1H-indazol-6-yl)piperazin-1-yl)-4-methyltetrahydrofuran-3-ol::US12319671, Example 12.1

SMILES COC12CC(n3cc(-n4ncc5cc(Cl)c(N6CCN([C@]7(C)COC[C@@H]7O)CC6)cc54)cn3)(C1)C2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 746184   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM746184((3R4R or 3S,4S)-4-(4-(5-chloro-1-(1-(3-methoxybicy...)
Affinity DataIC50: 625nMAssay Description:Assays were performed in the presence of 134 μM ATP (Km ATP). Upon completion, the assay was stopped, and phosphorylated substrate detected with a te...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/25/2025
Entry Details
US Patent