BDBM746199 (3R,4R or 3S,4S)-4-(4-(1-(1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl)-5-chloro-1H-indazol-6-yl)piperazin-1-yl)-4-methyltetrahydrofuran-3-carbonitrile (Ex. 14.1) and (3S,4R or 3R,4S)-4-(4-(1-(1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl)-5-chloro-1H-indazol-6-yl)piperazin-1-yl)-4-methyltetrahydrofuran-3-carbonitrile (Ex. 14.2::US12319671, Example 14.2

SMILES C[C@]1(N2CCN(c3cc4c(cnn4-c4cnn(C56CC(C5)C6)c4)cc3Cl)CC2)COC[C@H]1C#N

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 746199   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM746199((3R,4R or 3S,4S)-4-(4-(1-(1-(bicyclo[1.1.1]pentan-...)
Affinity DataIC50: 278nMAssay Description:Assays were performed in the presence of 134 μM ATP (Km ATP). Upon completion, the assay was stopped, and phosphorylated substrate detected with a te...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/25/2025
Entry Details
US Patent