BDBM746211 (1S,2S or 1R,2R)-2-(4-(1-(1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl)-5-chloro-1H-indazol-6-yl)piperazin-1-yl)-2-methylcyclobutan-1-ol (Ex. 19.1) and (1R,2R or 1S,2S)-2-(4-(1-(1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl)-5-chloro-1H-indazol-6-yl)piperazin-1-yl)-2-methylcyclobutan-1-ol (Ex. 19.2)::US12319671, Example 19.1

SMILES C[C@]1(N2CCN(c3cc4c(cnn4-c4cnn(C56CC(C5)C6)c4)cc3Cl)CC2)CC[C@@H]1O

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 746211   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM746211((1S,2S or 1R,2R)-2-(4-(1-(1-(bicyclo[1.1.1]pentan-...)
Affinity DataIC50: 555nMAssay Description:Assays were performed in the presence of 134 μM ATP (Km ATP). Upon completion, the assay was stopped, and phosphorylated substrate detected with a te...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/25/2025
Entry Details
US Patent