BDBM747213 (6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)(5-((S)- 7,7-difluorohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)pyrimidin-2- yl)methanone::US20250179079, Compound Rac-50

SMILES CC1c2c([nH]c3c(Cl)c(Cl)ccc23)CCN1C(=O)c1ncc(N2CCN3CC(F)(F)C[C@H]3C2)cn1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 747213   

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM747213((6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-pyrid...)
Affinity DataIC50: 89.5nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent